不同剂量地尔硫卓对冠心病患者PCI术后心功能的影响

Effects of Different Doses of Diltiazem on Cardiac Functions of Patients with Coronary Heart Diseases after PCI

目的:观察冠心病患者在经皮冠状动脉介入术(percutaneous coronary intervention,PCI)治疗后应用不同剂量地尔硫卓治疗的价值。方法 :回顾性分析2017年2月—2018年10月于我院行PCI术治疗的冠心病患者68例的临床资料,依据用药剂量的不同分为观察组(高剂量地尔硫卓治疗,n=34)与对照组(低剂量地尔硫卓治疗,n=34),比较两组心功能[左心射血分数(left ventricular ejection fractions,LVEF)、左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)及左心室收缩末期内径(left ventricular end systolic diameter,LVESD)]、心肌酶谱指标[肌钙蛋白I(cardiac troponin I,cTnI)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB)]。结果 :两组术后LVEF均高于术前,LVEDD及LVESD均低于术前,且观察组变化幅度大于对照组,差异有统计学意义(P <0.05);观察组术后cTnI及CK-MB峰值均低于对照组,差异有统计学意义(P <0.05)。结论 :针对冠心病患者,在PCI术后给予高剂量地尔硫卓治疗可明显促进心功能改善,增加心肌保护,利于疾病转归。

Objective:To observe the the value of different doses of diltiazem in patients with coronary heart diseases after percutaneous coronary intervention(PCI).Methods:The clinical data of 68 patients with coronary heart diseases undergoing PCI in our hospital from February 2017 to October 2018 were retrospectively analyzed,and the patients were divided into an observation group(high-dose diltiazem,n=34)and a control group(low-dose diltiazem,n=34)according to different doses of medication.The cardiac functions[left ventricular ejection fractions(LVEF),left ventricular end-diastolic dimension(LVEDD),left ventricular end systolic diameter(LVESD)]and myocardial enzyme indexes[cardiac troponin I(cTnI),creatine kinase isoenzymes(CK-MB)]were compared between the two groups.Results:The LVEF after surgery was higher than that before surgery,while the LVEDD and LVESD were lower than those before surgery,and the changing amplitude in the observation group was larger than that in the control group,with statistically significant differences(P<0.05).After surgery,the peak values of cTnI and CK-MB in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion:High-dose diltiazem can significantly improve cardiac functions,increase myocardial protection and promote outcome of the disease for the patients with coronary heart diseases after PCI.