盐酸米诺环素联合阿奇霉素治疗非淋菌性宫颈炎疗效观察

Observation on Efficacy of Minocycline Hydrochloride Combined with Azithromycin in Treatment of Non-gonococcal Cervicitis

目的 :观察盐酸米诺环素联合阿奇霉素治疗非淋菌性宫颈炎的疗效。方法 :参照随机数字表法将我院2017年1月—2019年6月收治的80例非淋菌性宫颈炎患者分为两组,各40例。对照组采用阿奇霉素分散片(0.5 g,qd)治疗,观察组采用盐酸米诺环素(100 mg加入5%葡糖糖注射液500 mL中,静脉滴注,bid)联合阿奇霉素治疗,比较两组防御素水平、症状控制时间、不良反应发生率及病原体转阴率。结果:治疗后,两组人β防御素1(Humanβ-defensins-1,HBD-1)mRNA含量比较,差异无统计学意义(P> 0.05);治疗后观察组HBD-2、HBD-3 mRNA含量低于对照组,差异有统计学意义(P <0.05);观察组症状控制时间短于对照组,差异有统计学意义(P <0.05);治疗后,观察组解脲脲原体(UU)、沙眼衣原体(CT)及UU和CT病原体均转阴率均高于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 :盐酸米诺环素联合阿奇霉素治疗可降低非淋菌性宫颈炎患者的HBD mRNA表达,缩短症状控制时间,提高病原体转阴率,且安全性好。

Objective:To observe the efficacy of minocycline hydrochloride combined with azithromycin in treatment of non-gonococcal cervicitis.Methods:80 patients with non-gonococcal cervicitis admitted to our hospital from January 2017 to June 2019 were randomly divided into two groups,40 cases each group.The patients in the control group were treated with azithromycin(0.5 g,qd),and the patients in the observation group were treated with minocycline hydrochloride(100 mg drug was added to 5%glucose injection 500 mL,intravenous drip,bid)combined with azithromycin.The levels of defensins,the control time of symptoms,the incidence of adverse reactions and the negative conversion rate of pathogens were compared between two groups.Results:There was no statistically significant difference in the mRNA content of humanβ-defensins(HBD)after treatment between the two groups(P>0.05).After treatment,the mRNA contents of HBD-2 and HBD-3 in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The control time of symptoms in the observation group was less than that in the control group,with statistically significant difference(P<0.05).After treatment,the negative conversion rates of Ureaplasma urealyticum(UU),Chlamydia trachomatis(CT)and both UU and CT pathogens in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Minocycline hydrochloride combined with azithromycin can decrease the mRNA expression of HBD,shorten the control time of symptoms and increase the negative conversion rate of pathogens.