噻托溴铵联合特布他林与布地奈德治疗老年COPD的疗效观察

Observation on Efficacy of Tiotropium Bromide Combined with Terbutaline and Budesonide in Treatment of Senile COPD

目的:探讨噻托溴铵联合特布他林与布地奈德治疗老年慢性阻塞性肺疾病(COPD)的疗效。方法:选择2017年5月—2019年6月于我院接受治疗的老年慢性阻塞性肺疾病患者100例,按随机数字表法分为两组,各50例。对照组采用布地奈德(2 mg)联合特布他林(5 mg,bid)治疗,观察组在对照组基础上采用噻托溴铵粉(18μg,qd)治疗。比较两组治疗效果、肺功能各项指标及免疫功能水平。结果:治疗后,与对照组比较,观察组用力肺活量(FVC)、第1 s用力呼气容积(FEV1)、FEV1/FVC、CD4+及CD4+/CD8+水平均较高,CD8+水平较低,治疗总有效率较高,差异有统计学意义(P <0.05)。结论 :噻托溴铵联合特布他林与布地奈德治疗老年COPD的疗效理想,可有效改善患者肺功能和免疫功能。

Objective:To investigate the efficacy of tiotropium bromide combined with terbutaline and budesonide in treatment of senile chronic obstructive pulmonary disease(COPD).Methods:100 senile patients with COPD admitted to our hospital from May 2017 to June 2019 were selected and randomly divided into two groups,50 cases each.The patients in the control group were given budesonide(2 mg)and terbutaline(5 mg,bid),and the patients in the observation group were further treated with tiotropium bromide(18μg,qd).The efficacy,pulmonary function indexes and immune functions were compared between two groups.Results:After treatment,the levels of forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC,CD4+and CD4+/CD8+in the observation group were higher those in the control group,while the level of CD8+was lower,and the total effective rate were higher,with statistically significant differences(P<0.05).Conclusion:Tiotropium bromide combined with terbutaline and budesonide is effective,and can improve pulmonary functions and immune functions in the treatment of senile COPD.