单次预注右美托咪定对腹腔镜胆囊切除术患者术中血流动力学的影响

Effect of Single Pre-injection of Dexmedetomidine on Intraoperative Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy

目的 :探讨单次预注右美托咪定对腹腔镜胆囊切除术患者术中血流动力学的影响。方法 :选取2017年2月—2018年5月我院收治的腹腔镜胆囊切除术患者108例,参照随机数字表法分为对照组和观察组,各54例。麻醉诱导前,对照组患者采用静脉泵注0.9%氯化钠注射液,观察组患者采用静脉泵注右美托咪定(1μg/kg),比较两组不同时间段血流动力学[心脏排血指数(cardiac index,CI),每搏量(stroke volume,SV),每搏指数(strokeworkindex,SVI),每搏量变异度(stroke volume variation,SVV)]和不良反应发生情况。结果 :术毕,观察组CI、SV及SVI水平均高于对照组,SVV水平低于对照组,差异有统计学意义(P <0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P <0.05)。结论 :采用单次预注右美托咪定对腹腔镜胆囊切除术患者进行麻醉,能够有效维持患者的血流动力学稳定性,且安全性较高,值得临床推广使用。

Objective:To investigate the effect of single pre-injection of dexmedetomidine on intraoperative hemodynamics in patients undergoing laparoscopic cholecystectomy.Methods:108 patients undergoing laparoscopic cholecystectomy admitted to our hospital from February 2017 to May 2018 were selected and randomly divided into a control group and an observation group,54 cases each.Before anesthesia induction,the patients in the control group were given 0.9%sodium chloride injection via intravenous pumping,and the patients in the observation group were given dexmedetomidine(1μg/kg)via intravenous pumping.The hemodynamics at different time points[cardiac index(CI),stroke volume(SV),stroke work index(SVI),stroke volume variation(SVV)]and adverse reactions were compared between two groups.Results:After the end of operation,the levels of CI,SV and SVI in the observation group were higher than those in the control group,while the level of SVV was lower than that in the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion:Single preinjection of dexmedetomidine for anesthesia in patients undergoing laparoscopic cholecystectomy can effectively maintain the hemodynamic stability of the patients,which has higher safety and is worthy of clinical use.