欣母沛联合卡贝缩宫素对宫缩乏力性产后出血患者凝血功能的影响

Effect of Hemabate Combined with Carbetocin on Coagulation Function in Patients with Postpartum Hemorrhage due to Uterine Inertia

目的 :探讨欣母沛联合卡贝缩宫素对宫缩乏力性产后出血患者凝血功能的调节效果。方法 :选取2017年2月—2018年4月我院收治的宫缩乏力性产后出血患者86例,按照随机数字表法分成两组,各48例。对照组患者给予卡前列素氨丁三醇注射液(250μg)治疗,观察组患者在对照组基础上联合卡贝缩宫素(1~2g,q12h)治疗,比较两组凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原(FIB)]及不良反应(恶心、腹痛、腹泻、血压升高)发生情况。结果 :治疗前,两组APTT、PT及FIB水平比较,差异无统计学意义(P> 0.05);治疗10 d后,观察组APTT、PT值均高于对照组,FIB水平低于对照组,差异有统计学意义(P <0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P <0.05)。结论:欣母沛与卡贝缩宫素联合治疗宫缩乏力性产后出血患者,能显著改善患者的凝血功能,且安全性较高,值得临床推广应用。

Objective:To investigate the regulating effect of hemabate combined with carbetocin on coagulation function in patients with postpartum hemorrhage due to uterine inertia.Methods:86 patients with postpartum hemorrhage due to uterine inertia admitted to our hospital from February 2017 to April 2018 were selected and randomly divided into two groups:a control group and an observation group,48 cases each.The patients in the control group were treated with carboprost tromethamine injection(250μg),and the patients in the observation group were treated with carbetocin(1~2 g,q12 h)on the basis of the treatment in the control group.The coagulation function[activated partial thromboplastin time(APTT),prothrombin time(PT)and fibrinogen(FIB)]and adverse reactions(nausea,abdominal pain,diarrhea,elevated blood pressure)were compared between the two groups.Results:There were no statistically significant differences in the levels of APTT,PT and FIB between the two groups(P>0.05).After 10 days of treatment,the values of APTT and PT in the observation group were higher than those in the control group,while the level of FIB was lower than that in the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Hemabate combined with carbetocin can significantly improve the coagulation function of the patients in the treatment of postpartum hemorrhage due to uterine inertia,which is safe and worthy of clinical application.