非那雄胺对前列腺增生手术患者血管内皮功能及细胞凋亡率的影响

Effect of Finasteride on Vascular Endothelial Function and Apoptosis Rate in Patients Undergoing Benign Prostatic Hyperplasia Surgery

目的 :观察非那雄胺对前列腺增生手术患者血管内皮功能及细胞凋亡率的影响。方法 :选取我院2017年12月—2018年9月收治的108例前列腺增生患者,按随机数字表法分为两组,各54例。两组均实施经尿道前列腺等离子双极电切术(TUPKRP)治疗,对照组术前不予以药物治疗,观察组予以非那雄胺片(5 mg,qd)治疗,比较两组围术指标、血管内皮生长因子(VECF)、微血管密度(MVD)、细胞凋亡率及排尿情况。结果 :两组手术总用时、冲洗液容量、前列腺病变组织切除质量比较,差异无统计学意义(P> 0.05);观察组术中出血量较对照组低,差异有统计学意义(P <0.05);观察组VECF、MVD数量低于对照组,细胞凋亡率高于对照组,差异有统计学意义(P <0.05);与术前比较,两组术后国际前列腺症状评分(IPSS)均降低,且观察组较对照组低,差异有统计学意义(P <0.05)。结论 :对前列腺增生手术患者术前予以非那雄胺治疗,可减少术中出血量,改善血管内皮功能,提高细胞凋亡率,改善患者排尿情况。

Objective:To observe the effect of finasteride on vascular endothelial function and apoptosis rate in patients undergoing benign prostatic hyperplasia surgery.Methods:108 patients with benign prostatic hyperplasia admitted to our hospital from December 2017 to September 2018 were selected and randomly divided into two groups:a control group and an observation group,54 cases each.The patients in the two groups were given transurethral plasma kinetic resection of prostate(TUPKRP).The patients in the control group were not treated with drugs before operation,and the patients in the observation group were treated with finasteride tablets(5 mg,qd).The level of vascular endothelial growth factor(VECF),microvessel density(MVD),cell red apoptosis rate and urination were compared between the two groups.Results:There were no statistically significant differences in total operation time,irrigation fluid volume and the resection mass of prostate lesions between the two groups(P>0.05).The intraoperative bleeding volume in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The level of VECF and MVD in the observation group were lower than those in the control group,while the apoptosis rate was higher than that in the control group,with statistically significant differences(P<0.05).The International Prostate Symptom Score(IPSS)after operation was lower than that before operation,and the IPSS in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:Preoperative treatment with finasteride can reduce intraoperative bleeding volume,improve vascular endothelial function,increase apoptosis rate and improve urination in patients with BPH.