头孢哌酮/舒巴坦联合莫西沙星对严重脓毒症患者器官衰竭程度的影响

Effect of Cefoperazone/Sulbactam Combined with Moxifloxacin on Organ Failure Degree in Patients with Severe Sepsis

目的 :探讨头孢哌酮/舒巴坦联合莫西沙星对严重脓毒症患者器官衰竭程度的影响。方法 :回顾性分析2017年3月—2018年11月我院收治的84例严重脓毒症伴器官衰竭患者的临床资料,根据治疗方案的不同分为对照组与观察组,各42例,对照组采用头孢哌酮/舒巴坦(3 g溶入定量0.9%氯化钠注射液稀释,ivgtt,bid)治疗,观察组采用头孢哌酮/舒巴坦联合莫西沙星(0.4 g溶入定量0.9%氯化钠注射液稀释,ivgtt,qd)治疗。两组均连续治疗2周,比较两组治疗前后炎症因子水平、白细胞计数、器官衰竭程度及不良反应发生情况。结果 :治疗后,观察组C反应蛋白、降钙素原、白细胞介素-6水平及白细胞计数均低于对照组,差异有统计学意义(P <0.05);治疗后,观察组器官衰竭评分(sequential organ failure assessment,SOFA)低于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P <0.05)。结论 :头孢哌酮/舒巴坦联合莫西沙星治疗严重脓毒症伴器官衰竭的疗效良好,可减少患者炎症反应,改善器官衰竭程度,且安全性高。

Objective:To investigate the effect of cefoperazone/sulbactam combined with moxifloxacin on the degree of organ failure in patients with severe sepsis.Methods:The clinical data of 84 patients with severe sepsis and organ failure admitted to our hospital from March 2017 to November 2018 were retrospectively analyzed.The patients were divided into a control group and an observation group according to different treatment schemes,42 cases each.The patients in the control group were treated with cefoperazone/sulbactam(3 g drug was dissolved in 0.9%sodium chloride injection and diluted,ivgtt,bid),and the patients in the observation group were treated with cefoperazone/sulbactam combined with moxifloxacin(0.4 g drug was dissolved in 0.9%sodium chloride injection and diluted,ivgtt,qd).The patients in the two groups were treated continuously for 2 weeks.The levels of inflammatory factors,white blood cell count and organ failure degree before and after treatment and adverse reactions were compared between the two groups.Results:After treatment,the levels of C-reactive protein,procalcitonin,interleukin-6 and white blood cell count in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the sequential organ failure assessment(SOFA)in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Cefoperazone/sulbactam combined with moxifloxacin is effective in the treatment of severe sepsis with organ failure,which can reduce patients’inflammatory response and improve the degree of organ failure,and has high safety.