畅心饮对冠心病患者微量白蛋白与血浆血管紧张素Ⅱ水平的影响

The Impacts of Changxinyin Decoction on the Levels of Albuminuria and Serum AngiotensinⅡin Patients with Coronary Heart Disease

目的观察畅心饮治疗对冠心病患者尿微量白蛋白(UACR)、血清血管紧张素Ⅱ(AngⅡ)水平的影响,探讨其对血管内皮的保护作用,以及这种保护作用与抗血管紧张素Ⅱ(AngⅡ)水平的关系。方法将86例冠心病患者分为两组,对照组行规范西医治疗,治疗组行规范西医治疗基础上加用畅心饮口服。观察两组临床疗效及治疗前后尿微量白蛋白和血清AngⅡ水平的变化。结果治疗组临床疗效总有效率为76.1%,高于对照组的52.5%,差异有统计学意义(P<0.05);治疗组治疗后与治疗前及对照组治疗后相比,UACR、AngⅡ水平显著下降(P<0.05),各组尿微量白蛋白和血清AngⅡ之间均存在着显著的相关性。结论对已经进行规范西医治疗的冠心病患者,畅心饮可进一步改善对血管内皮的保护作用,其机制与调控AngⅡ水平有关。

Objective To investigate the effects of Changxinyin decoction(CXYD)on the levels of albuminuria and serum angiotensinⅡ in patients with coronary heart disease(CHD).Methods Eighty six patients with CHD were randomly divided into two groups:The control group treated with routine treatment,and the treatment group treated with routine treatment plus CXYD.The clinical effica-cy,albuminuria and serum angiotensin Ⅱlevels were observed. Results The total clinical effective rate was 76. 1% in treatment group,which was higher than that in control group(52.5%,P<0.05).After treatment,the levels of albuminuria and serum angiotensinⅡ in treatment group were decreased,which was lower than that in control group(P<0.05).In addition,the albuminuria level dem-onstrated a significant relation to serum angiotensinⅡ level in each groups.Conclusion CXYD can furthere improve the clinical effi-cacy and ameliorate vascular endothelial protection in patients with CHD,and this protection is significantly related to their angioten-sin Ⅱlevels.