灾难性抗磷脂抗体综合征成功治疗1例

Successful treatment of catastrophic antiphospholipid syndrome:A case report

1病例资料患者,女,36岁,因'咳嗽、咳痰伴胸闷、胸痛14d'入住我科。患者于14d前开始出现咳嗽、咳痰,咳少许白痰,伴胸闷、胸痛,曾至某县医院就诊,但因患者妊娠28周未予检查。1周后患者胸痛加重,渐出现双下肢浮肿、血压增高至140/110mmHg(1mmHg=0.133kPa),自觉胎动消失,B超诊断为'宫内死胎'而后引产。

Catastrophic antiphospholipid antibody syndrome refers to a group of non-inflammatory autoimmune diseases in which a group of laboratory antiphospholipid antibodies are continuously positive with repeated arteriovenous thrombosis,thrombocytopenia,and abnormal pregnancy as the main clinical manifestations.The diseases develop insidiously and the mortality rate is very high.We report a 36-year-old woman with fever,cough and chest pain as the primary symptoms,which were initially misdiagnosed as common lung infection.After further examination,catastrophic antiphospholipid antibody syndrome was confirmed.Anticoagulant therapy and glucocorticoid were applied immediately,and she was fully recovered.It is a very easy misdiagnosed case in the emergency department.The purpose of sharing this case is to let the emergency doctor fully understand the disease and reduce misdiagnosis and mistreatment.