CBP联合胸腺肽α1在脓毒症患者中的疗效及对免疫功能的影响

The clinical efficacy of CBP combined with thymosin alphaα1 in the patients with sepsis and the effect on the immune function

目的:探析连续性血液净化(CBP)联合胸腺肽α1在脓毒症患者中的临床疗效及对免疫功能的影响作用。方法:分析2014-03—2017-03期间在我院ICU接受治疗的72例脓毒症患者的临床资料。根据治疗方式不同,将入选者分成观察组(CBP联合胸腺肽α1治疗,37例)和对照组(CBP治疗,35例)两组。比较两组患者的一般资料、临床疗效、治疗前后的炎性因子及免疫功能情况。结果:两组患者的年龄、性别及BMI值等一般资料差异无统计学意义(P>0.05)。治疗后观察组患者的临床疗效明显优于对照组(P<0.05)。治疗前两组患者的炎性因子及免疫功能差异无统计学意义(P>0.05)。治疗后观察组患者的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及CD8+比例均明显低于对照组,而CD3+、CD4+、HLA-DR比例及白细胞介素-10(IL-10)明显高于对照组(P<0.05)。治疗后两组患者的炎症状态及免疫功能均较治疗前有明显改善(P<0.05)。结论:CBP联合胸腺肽α1在脓毒症患者中具有突出的临床疗效,不但可以改善患者的炎症状态,而且有效纠正了患者的免疫紊乱现象。

Objective:To analyze the clinical efficacy of continuous blood purification(CBP)combined with thymosin alphaα1 in the patients with sepsis and the effect on the immune function.Method:Clinical data of 72 patients with sepsis received treatment at ICU at our hospital from March,2014 to March,2017 was retrospectively analyzed.Patients included were divided into two groups according to the treatment,observe group(CBP combined with thymosin alphaα1,37 cases)and control group(CBP,35 cases).The general information,the clinical efficacy,the levels of inflammatory factors and immune function indexes before and after treatment in two groups were compared.Result:The general information in two groups had no statistical difference(P>0.05).The clinical efficacy in observe group were obviously better than that in control group(P<0.05).Before treatment,the levels of inflammatory factors and immune function indexes in two groups had no statistical difference(P>0.05).After treatment,the levels of IL-6,TNF-αand CD8+percentage in observe group were obviously lower than those in control group,while the IL-10 level,CD3+,CD4+percentage and HLA-DR in observe group was obviously higher than that in control group(P<0.05).The inflammatory condition and immune function after treatment were better than those before treatment in two groups(P<0.05).Conclusion:The clinical efficacy of CBP combined with thymosin alphaα1 in treating the patients with sepsis is obvious,including the improvement of the inflammatory condition and immune system.