靶向激肽-激肽释放酶系统在原发性肝癌发生和发展中的研究进展

Progress in targeting kinin-kallikrein system in occurrence and development of primary hepatocellular carcinoma

激肽-激肽释放酶系统(kinin-kallikrein system,KKS)系机体内源性多蛋白级联反应系统;其激活可导致内源性凝血级联途径活化并促使激肽原酶解,进而释放缓激肽和胰激肽等相关肽。KKS参与炎性反应、血管生成、心脏保护、血管通透性、血压控制、凝血和疼痛等多种病理和生理过程,并与肝癌、前列腺癌和卵巢癌等多种肿瘤的病因病理密切相关。本文针对KKS在原发性肝癌进程中的作用以及干预KKS辅助治疗肝癌可能性的研究进展进行综述。

The kinin-kallikrein system(KKS)is a system of endogenous multiprotein cascades.Its activation leads to activate the intrinsic coagulation cascade pathway and promote the enzymatic hydrolysis of kininogens with the consequent release of bradykinin and pancreatic peptides.KKS is involved in various pathophysiological processes such as inflammation,angiogenesis,cardioprotection,vascular permeability,blood pressure control,coagulation and pain.And KKS is closely related to the etiologic and pathologic progression of liver cancer,prostatic carcinoma and ovarian cancer.This review focuses on the role of KKS in the occurrence and development of hepatocellular carcinoma and the progress in the intervention of KKS in the treatment of hepatocellular carcinoma.