还精煎延缓衰老的临床研究附62例疗效观察

A Clinical Study of the Effect of Essence-Restoring Decoction on Retarding Aging Process——A Report of 62 Cases

本文报告补肾中药还精煎廷缓衰老的研究结果。以免疫功能、肺容量及通气功能、肌酐、近视力、握力、抗核抗体,类风湿因子、X 线右股骨皮质指数测定为临床指标,疗程一年。结合昆明种小鼠、家蚕蚕蛾生存期及有关基础研究作出评价。临床及实验提示还精煎有一定的延缓衰老作用。

This paper presents the effect of a kidney tonifying Chinese medicine"Essence-Restoring Decoction"on retarding the process of aging.Clinical indices such as immune function,lung volume,ventilation function, serum creatinine,near visual acuity,grip strength,anti-nuclear antibody(ANA),rheumatoid factor(RF),and X-raying of the right femur for measurement of the periosteum index have been adopted.Duration of treatment is one year.The assessment of the therapeutic effect is based on the integration of the survival time of mice(Kunming breeding)and silkworms fed with this decoction.Post-treatment mean value shows that the indices of lymphocyte transformation,activated T lymphocyte,total complement,C_3,IgG,vital capacity, maximal ventilation capacity,near visual acuity,grip strength,periosteum index in presenile and senile stages all have a rise.ANA turns to negative.The presenile stage residual volume/total lung capacity ratio and one second expiratory volume have reduced.The senile stage IgM rises,IgA and alternative pathway complement are reduced.The other laboratory estimates maintain the same level as one year before.The rise of lymphocyte transformation,presenile stage C_3,senile stage IgM and vital capacity is of statistical significance (P<0.05—0.01).Comparing with that of the controls,the survival time of Kunming breeding mice and moths of the silkworms is prolongated significantly(P<0.05).Morphology study of medicated 26-month old mice proves that the senility of ovarium,matrix and testis has been retarded;the submicroscopic observation demonstrates that the decoction has protective action on liver cells.It is capable of promoting energy metabolism and synthesis of nucleic acid and protein,improving the survival capacity of lymphocytes in vitro,inhibiting the formation of autogenous rosette,raising lung cAMP content and cAMP/cGMP ratio of the liver and lung,retarding the decrease of bone capacity.As is suggested by clinical and experimental studies the Essence-Restoring Decoction has some effect on retarding aging.