中西医结合治疗葡萄胎化疗反应

Experience in TCM-WM Treatment of the Side Effects of Trophoblastic Tumor Chemotherapy

对30例滋养细胞肿瘤化疗患者61疗程进行了中西医结合治疗,其化疗同时服中药的41疗程,停化疗后服中药的20疗程,并取同期同条件不服中药的41疗程作为对照。临床分析比较了化疗的毒性反应和骨髓抑制作用。从化疗中白血球、血小板未变化率及消化道反应、口腔溃疡、发烧重反应的发生率来看,化疗中用药组之疗效比其它二组为佳(P<0.05)。

A total of 30 cases and 61 courses treated with TCM-WM were compared with 41 courses without TCM therapy.The patients were divided at random into three groups.Group 1 were treated with TCM during the course of chemotherapy.Group 2 were treated with TCM after the course.Group 3 were treated with WM only.The chemotherapy was carried out with 5Fu 25-26mg/kg and combined with Actinomycin 5-6μg/kg for 8 days or 5Fu 25-30mg/kg for 10 days or Actinomycin 7-9μg/kg for 10 days respectively.According to the diagnosis and treatment with TCM,the side effects were divided into 3 types,namely,upwardly perverse Qi of the stomach,endogenous heat due to deficiency of Yin,and deficiency of both Qi and Yin.The effectiveness of each type treated with a definite recipe was observed. The unchanged rates of leukocyte in the 3 groups were 75.6%,40%,41.6% and those of the blood platelet were 95.1%,70%,78.1% respectively.It showed that the results of group 1 was significantly higer than the others(P <0.05).There were only two cases(4.8%)with serious side effects in the digestive tract,but no serious ulcerative stomatitis and high fever in group 1.The differences were significant between group 1 and the other two groups(p <0.01.)