棉酚快速用药法治疗妇科病远期疗效——72例临床分析

The Late Effect of Gossypol Treatment in Gynecological Diseases—A Clinical Study of 72 Cases

报告72例完成棉酚治疗一疗程后停药随访观察结果。晚期疗效满意,作用持久且可逆。63.6%病例闭经持续半年以上,9.1%闭经1年以上。停药后80.4%半年内月经恢复。恢复后症状和体征均有不同程度好转。子宫出血、痛经、肌腺病或肌瘤、内膜异位症的远期有效率分别为47.1%、58.1%、63.0%、58.3%。

The late results of 72 cases of gynecological diseases after discontinuation of gossypol treatment are reported. The longest follow-up periodwas 4 years. There were 31 cases ofmyoma,14 of adenomyosis,14 ofendometriosis and 13 of myoma or adenomyosis with endometriosis. The late effect was satisfactory.The action was sustained and reversible.Amenorrhea continued for halfa year in 63.6%,and for one year in 10.0%.After discontinuation of medication,menstruation returned within halfa year in 80.4% of the cases.The symptom and sign usually improved:the effective rate of uterine bleeding was 47.1%, dysmenorrhea 58.1%,reduction of myoma size 63.0% and reduction of endometriotie nodules 58.3%. The recurrence of dysmenorrhea was related with the length of the course of treatment,clinical stage and the estrogen level of vaginal smear recovered.The recurrence of myoma and bleeding was related with age and their pretreatment estrogen level. There was no side-effect in the follow-up study.The action of gossypol is similar with danazol.Sharp vigilance must be maintained on the possibility of hypokalemia.