生脉散对冠心病心气虚患者左心功能的影响

Effects of Shen Mai San(生脉散)on the Left Ventricular Performance in Patients with Deficiency of Heart-Vital Energy in Coronary Heart Disease

本文报告采用电子计算机"中心触发平均程序"进行无创伤性人体左心功能测定。观察了健康成年人、冠心病伴中医辨证为心气虚病人各20例的左心功能及静脉注射生脉散对患者左心功能的影响。结果表明,冠心病心气虚患者均有程度不同的左心功能不全,生脉散有改善左心功能的即时效应。

Systolic time intervals(STI)were used to examine the left ventricular performance in 20 patients with deficiency of heart-vital energy in the coronary heart disease and 20 normal healthy subjects. Simultaneous ECG(1ead Ⅱ),phonocardiogram(PCG),carotid pulse tracing and apexcardiogram were recorded for the measurement of STI in conventional manner.At the same time,the signals were recorded on an analogic tape recorder.Then it was fed into the computer and processed by the specific triggered average program. The processed waveform was copied by an X-Y plotter and presented on a CRT display.The data of STI was read out on CRT or by a printer. The heart rate(HR),the electromechanical time(EMT),left ventricular ejection time(LVET),mechanical systole time(MST),isovolumic contraction time(ICT),isovolumie relaxation time(IRT),pre-ejection period(PEP), EMT index,PEP index,LVET index,PEP/LVET,PEPI/LVET and LVET/ICT were measured. Recordings were obtained lhr before and after intravenous injection of Shen Mai San(consisting of three Chinese herbal medicines).The results of our study showed that the left ventricular function in patients with deficiency of heart-vital energy in the coronary heart disease was decreased or impaired to a certain degree.After intravenous injection of Shen Mai San,there was a significant decrease in HR,PEP,ICT,IRT and PEP/LVET and a significant increase in LVET statistically.It indicates that the left ventricular function was improved by intravenous injection of Shen Mai San.