基于复杂网络的不稳定型心绞痛中药配伍应用规律研究

Combination Rules of Chinese Herbal Prescriptions for Treating Unstable Angina Based on Complex Network

目的探索中医药治疗冠心病不稳定型心绞痛(unstable angina,UA)有效病例的用药配伍规律。方法以中国中医科学院西苑医院心血管中心中西医结合治疗UA的有效病例156例为基础,利用复杂网络分析方法,挖掘中医药治疗UA的用药配伍规律。结果通过多尺度骨干网络分析和互信息分析,UA症状改善病例的核心用药主要有川芎、赤芍、党参、半夏、茯苓、当归,常用核心药物配伍有川芎与赤芍、当归与川芎、党参与川芎、川芎与半夏、白术与茯苓、薤白与半夏,针对不同主症用药配伍略有不同。结论本研究运用复杂网络探索挖掘了中医药治疗UA有效病例的用药配伍规律,其核心用药主要包括活血药、益气药和化瘀药,可作为未来进一步深入研究的参考。

Objective To explore combination rules of Chinese herbal prescriptions from effective cases for treatment of unstable angina( UA). Methods Prescription data from 156 UA patients effectively treated at Cardiovascular Diseases Centre of Xiyuan Hospital were analyzed using complex network method. Results According to multi- scale analysis of backbone network and pointwise mutual information analysis,core prescriptions from the 156 UA patients were presented as follows:Rhizoma Ligustici wallichii,Radix Paeoniae rubra,Radix Codonopsis,Rhizoma Pinelliae,poria,and Angelica sinensis. Meanwhile,core couplet medicines for these patients coveredRhizoma Ligustici wallichii andRadix paeoniaerubra,Angelica sinensis andRhizoma Ligustici wallichii,Radix Codonopsis andRhizoma Ligustici wallichii,Rhizoma Ligustici wallichii andRhizoma Pinelliae,Rhizoma Atractylodis Macrocephalae and poriacocos,Bulbus Allii Macrostemi andRhizoma Pinelliae. Among different primary symptoms,there was slightly difference in core prescriptions. Conclusion The core prescriptions for the treatment of UA include blood- activating drug,phlem- resolving drugs. As an exploration of combination rules of Chinese herbal prescriptions in treating UA based on complex network,it can be used as a reference for further researches.