摘要
目的观察活血滋肾方治疗肾虚血瘀型免疫性卵巢早衰的临床疗效。方法将63例符合纳入标准的免疫性卵巢早衰患者采用随机表法分为两组,试验组(32例)服用中药汤剂活血滋肾方,对照组(31例)服用克龄蒙(戊酸雌二醇/雌二醇环丙孕酮片),治疗3个月。比较两组患者治疗前、治疗结束后Kuppermann评分,促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E_2)、抗缪勒管激素(AMH)和抑制素B(INHB)水平,抗核抗体(ANA)、抗环瓜氨酸肽(CCP)抗体水平。结果两组治疗后症状积分比治疗前均明显降低(P<0.05),试验组治疗后症状积分下降更为显著(P<0.05);治疗3个月后两组患者FSH、LH下降(P<0.05),E_2、AMH、INHB升高(P<0.05),其中试验组改善更为显著(P<0.05);对照组16例系统性红斑狼疮(SLE)患者ANA水平及15例类风湿关节炎(RA)抗CCP抗体水平治疗前后比较,差异均无统计学意义(P>0.05);试验组14例SLE患者ANA水平及18例RA患者抗CCP抗体水平治疗前后比较,差异亦无统计学意义(P>0.05)。结论活血滋肾方及克龄蒙都能改善肾虚血瘀型免疫性卵巢早衰患者的临床症状,改善性激素水平,但活血滋肾方效果优于克龄蒙。
Objective To study the clinical efficacy of Huoxue Zishen Recipe(HXZSR)in the treatment of immunological premature ovarian failure(POF)of Shen deficiency blood stasis syndrome(SDBSS).Methods Totally 63 patients with immunological POF in line with the inclusion criteria were assign to two groups by random table method.Patients in the experimental group(32 cases)took HXZSR,while those in the control group(31 cases)took Kelingmeng(Estradiol Valerate/Estradiol Cyproterone Tablets).The therapeutic course for all was 3 months.Kuppermann score,levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-Müllerian hormone(AMH),inhibin B(INHB),anti-nuclear antibody(ANA),and anti-cyclic proline peptide antibody(anti-CCP antibody)were compared between the two groups before and after treatment.Results The symptom scores were both significantly lower after treatment than before treatment in the two groups(P<0.05),and they decreased more significantly in the experiment group(P<0.05).After 3 months of treatment,FSH and LH decreased(P<0.05),E2,AMH and INHB increased(P<0.05)in the two groups,and they were more significantly improved in the experimental group(P<0.05).In the control group no significant differences existed in the ANA level of 16 systemic lupus erythematosus(SLE)patients and in anti-CCP antibody levels of 15 rheumatoid arthritis(RA)patients between before and after treatment(P>0.05).In the experimental group no significant differences existed in the ANA level of 14 SLE patients and in anti-CCP antibody levels of 18 RA patients between before and after treatment(P>0.05).Conclusion HXZSR and KLM improved clinical symptoms of immunological POF patients with SDBST and elevated the levels of sex hormones,but HXZSR showed better effects.
作者
曾富玲
孙维峰
李静
梁静
ZENG Fu-ling;SUN Wei-feng;LI Jing;LIANG Jing(Department of TCM,Guangzhou Military Region Guangzhou General Hospital,Guangzhou 510010;Graduate School,Guangzhou University of TCM,Guangzhou 510405)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2019年第5期536-541,共6页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
免疫性卵巢早衰
肾虚血瘀
活血滋肾方
临床研究
immunological premature ovarian failure
Shen deficiency blood stasis
Huoxue Zishen Recipe
clinical research