基于聚类分析和因子分析对寻常型银屑病中医外治用药规律的研究

Study on Medication Laws of Chinese Medicine External Treatment for Psoriasis Vulgaris Based on Cluster Analysis and Factor Analysis

目的探究寻常型银屑病中医外治方药物组方配伍规律。方法检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中国中医药文献检索系统数据库(TCM),对1979—2016年所报道的寻常型银屑病外治方药文献进行查找,利用Excel建立方药数据库,对收集的数据进行方剂和中药的规范,应用SPSS 22.0进行频数分析、聚类分析和因子分析。结果最终符合要求的文献369篇,方剂400首,频数3 033次,中药以清热药(36.1%)、杀虫止痒药(10.0%)、活血化瘀药(9.1%)、补虚药(8.2%)、解表药(7.6%)、利水渗湿药(5.0%)为主。43味高频药物出现频数占总比>70.3%,可分为5个聚类方,其KMO值为0.612,Bartlett球形度检验P<0.05,适于因子分析,得出17个公因子。结论寻常型银屑病从血分辨证论治,中医外治原则以清热凉血、活血化瘀、养血润燥为主,同时配合解毒祛风、燥湿杀虫止痒。

Objective To observe the compatibility laws of Chinese medicine external treatment for psoriasis vulgaris.Methods An electronic search of Chinese journal full text database(CNKI),Chinese biomedical literature database(CBM),and traditional Chinese medicine database system(TCM)from 1979 to 2016,involving Chinese medicine external treatment for psoriasis vulgaris related literatures was performed.Database was established using Excel to standardize collected Chinese medical recipes and herbs data.Frequency analysis,cluster analysis,and factor analysis were performed using SPSS 22.0.Results A total of 369 articles were included with 400 formulas,and the frequency was 3033.Chinese herbs dominated were clearing heat herbs(36.1%),insecticidal and antipruritic herbs(10.0%),blood activating stasis dissolving herbs(9.1%),tonifying herbs(8.2%),exterior relieving herbs(7.6%),diuresis removing herbs(5.0%).The 43 kinds of Chinese herbs with high frequency accounted for more than 70.3%,which could be divided into 5 cluster recipes.They met the criteria for factor analysis because the KMO value was 0.612 and the Bartlett sphericity test was P<0.05.Finally,17 common factors were extracted from factor analysis.Conclusions Psoriasis vulgaris was mainly syndrome differentiated from blood aspect.The therapeutic principles of Chinese medical external treatment for psoriasis vulgaris were clearing heat and cooling blood,activating blood and dissolving stasis,tonifying blood deficiency and moistening dryness,complicated with detoxicating and removing wind,eliminating dampness,killing parasites and relieving itches.