急性脑梗死患者血浆骨桥蛋白水平与颈动脉内膜中层厚度的相关性研究

The relationship between plasma osteopontin and carotid intimal medial thickness in acute cerebral infarction

目的探讨急性脑梗死患者血浆骨桥蛋白(OPN)水平与颈动脉内膜中层厚度(IMT)的关系。方法选择符合急性脑梗死诊断标准的患者150例,选择同期来院体检的健康志愿者65例为对照组;将脑梗死组按颈动脉IMT值分为ACI无颈动脉斑块组74例和ACI合并颈动脉斑块组76例;检测所有研究对象的血浆OPN水平,通过颈动脉多普勒超声测量颈总动脉IMT值。结果 ACI无颈动脉斑块组血浆OPN水平较对照组升高(P<0.05);ACI合并颈动脉斑块组血浆OPN水平较对照组升高更显著。ACI患者血浆OPN水平与颈动脉内膜中层厚度(rs=0.291,P<0.05)呈正相关。结论急性脑梗死患者血浆OPN水平升高,且与颈动脉内膜中层厚度呈正相关,提示OPN可能参与急性脑梗死患者动脉粥样硬化的发生、发展。

Objective To investigate the relationship between plasma osteopontin level and carotid intimal medial thickness in patients with ACI.Methods 150 cases of acute cerebral infarction were Selected as cerebral infarction group.65 healthy subjects were collected as controls depending on routine health examination.Carotid intima media thickness(IMT)was measured with color Doppler ultrasound.The patients were divided into ACI group without carotid artery atherosclerosis(74 cases)and ACI group with carotid artery atherosclerosis(76 cases),depending on IMT.Plasma osteopontin levels were determined in 150 ACI patients and 65 healthy controls respectively.Results Plasma osteopontin levels were increased in 74 essential ACI patients with IMT<1.0 mm as compared with 65 healthy controls.Plasma osteopontin levels were increased more significantly in 76 ACI patients with IMT≥1.0 mm as compared with 65 healthy controls.A positive relationship was found between IMT and plasma osteoponin level in ACI patients(rs=0.291,P<0.05).Conclusion Plasma osteoponin level increased in ACI patients,especially in the patients with carotid atherosclerosis.Plasma osteoponin level was positively correlated with carotid IMT,which suggested the role of osteoponin in process of atheroscterosis.