神经生长因子辅助治疗高血压性脑出血的效果及对水通道蛋白、氧化应激因子水平的影响

The effects of nerve growth factor on cell factors,recovery of nerve function defect and quality of daily life of the patients with hypertensive intracerebral hemorrhage (HICH)

目的分析神经生长因子辅助治疗高血压性脑出血(HICH)的效果及对水通道蛋白、氧化应激因子水平的影响。方法选取本院2016年2月-2017年12月收治的HICH患者74例,根据治疗方法不同分为对照组和观察组;对照组患者采用常规治疗,观察组患者采用常规治疗+神经生长因子治疗,分析2组患者治疗后的临床效果。结果治疗前2组患者血肿量、水肿体积、NIHSS评分和Barthel指数评分比较无明显差异(P>0.05);治疗后观察组患者血肿量、水肿体积、NIHSS评分低于对照组,Barthel指数评分高于对照组(P<0.05)。治疗前2组患者MMP-9、SOD、GSH-Px、AQP-1、AQP-4水平比较无明显差异(P>0.05);治疗后观察组患者SOD、GSH-Px水平高于对照组,MMP-9、AQP-1、AQP-4水平低于对照组(P<0.05)。结论神经生长因子辅助治疗HICH可缩小水肿体积,降低MMP-9、AQP蛋白水平,提高SOD、GSH-Px水平,促进神经功能缺损恢复,提高日常生活质量。

Objective To analyze the effects of nerve growth factor(NGF)on cell factors,the recovery of nerve function defect and the quality of daily life of the patients with hypertensive intracerebral hemorrhage(HICH).Methods From February 2016 to December 2017,74 patients with HICH were selected and divided into control group and observation group according to different treatment methods.The patients in the control group were treated with routine therapy,and the patients in the observation group were treated with nerve growth factor.Results Before treatment,there were no significant differences in hematoma volume,edema volume and NIHSS score and Barthel index score between the two groups(P>0.05).After treatment,the scores of hematoma volume,edema volume and NIHSS in the observation group were lower than those in the control group(P<0.05),and the scores of Barthel index in the control group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences between the two groups in the levels of MMP-9/SODX GSH-PxAAQP-1and AQP-4(P>0.05).After treatment,the levels of MMP-9,AQP-1,AQP-4 of the observation group were significantly lower than those of the control group(P<0.05).Conclusion Nerve growth factor adjuvant treatment of HICH could reduce the volume of edema,the levels of MMP-9,AQP protein,promote the recovery of nerve function defect and improve the quality of daily life.