补肾益髓法对帕金森病肾虚髓减证患者非运动症状的影响

Effects of Tonifying Kidney and Benefiting Marrow Method on Non-motor Symptoms of Parkinson's Disease with Kidney Deficiency and Marrow Reduction

目的观察补肾益髓法治疗帕金森病肾虚髓减证患者非运动症状的疗效。方法将60例帕金森病肾虚髓减证患者随机分为治疗组和对照组各30例,两组均以抗帕金森病西药治疗为基础,治疗组加用补肾益髓法方药治疗3个月,于治疗前及治疗1、3个月进行帕金森病睡眠量表(PDSS)、疲劳量表、嗜睡量表、便秘量表评分,于治疗前和治疗3个月采用蒙特利尔认知评估量表(MoCA)进行评分,并判定临床疗效。结果治疗3个月,治疗组临床疗效总有效率为90. 00%,对照组为66. 67%,治疗组总有效率高于对照组(P <0. 05)。治疗组治疗3个月PDSS、疲劳量表、嗜睡量表、便秘量表评分均较本组治疗前降低,且低于同时间对照组(P <0. 05);两组治疗前后MoCA评分差异无统计学意义(P> 0. 05)。结论补肾益髓法可改善帕金森病肾虚髓减证患者疲劳、日间嗜睡、睡眠障碍、便秘等非运动症状。

Objective To explore the effects of tonifying kidney and benefiting marrow method on non-motor symptoms of Parkinson’ s disease with kidney deficiency and marrow reduction. Methods A total of 60 patients with Parkinson’s disease with kidney deficiency and marrow reduction were randomly divided into a treatment group and a control group. Both groups were treated based on the western medicine of anti-Parkinson’ s disease,and the treatment group was added with the recipe of tonifying kidney and benefiting marrow method for 3 months. The Parkinson disease sleep scale( PDSS),fatigue scale,Epworth somnolence scale,and constipation scale were scored before treatment,1 and 3 months after treatment. The Montreal cognitive assessment scale( MoCA) was used to explore the clinical effects. Results After 3 months’ treatment,the total effective rate was 90. 00% in the treatment group,and 66. 67% in the control group,the treatment group significantly higher than the control group( P < 0. 05). After 3 months’ treatment,scores of the PDSS,fatigue scale,Epworth somnolence scale,and constipation scale of the treatment group were lower than before treatment,and lower than the control group at the same time( P < 0. 05). There was no difference in the MoCA score of the 2 groups before and after treatment( P > 0. 05). Conclusion Tonifying kidney and benefiting marrow method is effective in improving the non-motor symptoms of Parkinson’ s disease with kidney deficiency and marrow reduction,such as fatigue,daytime sleepiness,sleep disorders and constipation.