基于肝-肠轴探讨“实脾法”治疗肝癌的科学内涵

Scientific Connotation of Liver Cancer Treated by “Reinforcing Spleen Method” based on Gut-Liver Axis

肝和脾在生理、病理上有密切的联系,"实脾法"治疗肝癌是中医整体观念和"治未病"的重要体现,历代医家在此基础上论治肝病成效显著。随着肝-肠轴学说研究的深入,发现通过胃肠道多种途径调节肝-肠轴上行通道,如肠道黏膜屏障、内毒素、肠道菌群等对肝功能均具有调节作用。大量的证据表明,调节肠道稳态是治疗肝癌等肝病的潜在途径,从中医理论出发,结合临床应用,并联系肝-肠轴学说,探讨"实脾法"在原发性肝癌治疗中的科学内涵。

The liver and spleen are closely related in physiology and pathology.The'reinforcing spleen method'for the treatment of liver cancer is an important manifestation of the holistic concept and the preventive treatment of diseases in traditional Chinese medicine(TCM).Generations of physicians have been effectively treating liver disease with this method.Along with in-depth study of the theory of gut-liver axis,it was found that gastrointestinal tract can adjust the liver function through several ways of gut-liver axis uplink channels,such as intestinal mucosa barrier,endotoxins,intestinal flora,having liver-regulating function.More and more evidence shows that regulating intestinal homeostasis is the potential pathways in treating liver cancer and other liver diseases.Therefore,this paper from the theory of TCM,combined with clinical application,and linked to the theory of gut-liver axis,aimed to explore the scientific connotation of'reinforcing spleen method'in the treatment of primary liver cancer.