黏附分子-1对鼻息肉中嗜酸性粒细胞聚集及临床预后的意义

Role of ICAM-1 in eosinophilia and prognosis of nasal polyps

目的 :探讨黏附分子 1(ICAM 1)在鼻息肉中的表达及对嗜酸性粒细胞聚集和临床预后的意义。方法 :采用荧光免疫组织化学法检测 35例慢性鼻窦炎、鼻息肉患者 (鼻息肉组 )的鼻息肉组织及 15例慢性鼻炎患者 (对照组 )的下鼻甲黏膜中ICAM 1的表达并进行定量分析。结果 :鼻息肉组和对照组嗜酸性粒细胞平均计数分别为 (2 8.4± 10 .7)个 /mm2 和 (9.9± 8.6 )个 /mm2 ,ICAM 1相对荧光强度为 115 .9± 82 .4和 2 8.2± 17.1,随鼻息肉严重程度的加重 ,ICAM 1的表达强度逐渐增高。结论 :ICAM 1对鼻息肉中嗜酸性粒细胞的聚集及鼻息肉的预后具有重要的意义 。

Objective:To investigate the role of adhesion molecule ICAM-1(Intercellular adhesion molecule-1) in eosinophilia and prognosis of nasal polyps.Method:Expression of ICAM-1 were detected and quantified in 35 cases of nasal polyps with fluorescence-immunohistochemistry analysis and its relationships to eosinophilia and prognosis of nasal polyps were evaluated.Result:The numbers of eosinophils in nasal polyps and control nasal mucosas were 28.4± 10.7/mm 2 and 9.9± 8.6/mm 2, and fluorescent densities of ICAM-1 were 115.9± 82.4 and 28.2± 17.1. The expression of ICAM-1 was associated with the heaviness of nasal polyps.Conclusion:ICAM-1 may play an important role in the formation and prognosis of nasal polyps