摘要
本实验观察了大鼠全身照射不同剂量(4～25Gy)及全腹部照射(10Gy)后胃酸分泌的变化并用RIA方法测定照射后胃窦及血清中胃泌素水平.结果表明,全身8～25Gy照射后第3天,腹部10Gy照射后1～6周,胃酸分泌明显抑制.主现表现为胃液中[H^+]分泌的抑制,致使照射后胃液酸度降低.10Gy以上剂量照射使胃泌素释放增加,表现为血清胃泌素明显升高,胃窦胃泌素明显减少,导致照射引起的"低胃酸、高胃泌素血症".这种表现与人的某些萎缩性胃炎或恶性贫血的状况相似.
The changes of gastric acid secretion and the gastrin levels in antrum and serum after 4-25 Gy whole body irradiation and 10 Gy local irradiation of the whole abdominal region of rats were investigated.
The results showed that the gastric acid secretion was inhibited significantly on 3rd day after 8-25 Gy whole body irradiation and in 1-6 weeks after 10 Gy local irradiation of whole abdomen.The antrum gastrin decreased and serum gastrin increased simultaneously after irradiation.These changes are similar to those of some atrophic gastritis and pernicious anemia in human being.
出处
《军事医学科学院院刊》
CSCD
北大核心
1989年第2期84-87,共4页
Bulletin of the Academy of Military Medical Sciences
关键词
电离辐射
胃酸分泌
胃泌素
大鼠
ionizing radiation
gastric acid secretion
gastrin
whole abdomen expose
rat
