硒对颗粒活性炭净化水毒性的防护作用

THE PROTECTIVE EFFECTS OF SELENIUM ON THE TOXICITY OF DRINKING WATER TREATED BY GRANULAR ACTIVATED CARBON (GAC)

本文对颗粒活性炭净化饮水的亚慢性毒性、遗传毒性和对细胞免疫功能的影响及硒对以上毒性作用的防护作用进行了试验研究。研究选用昆明和BALB/C两种小鼠。实验周期100天。结果显示,颗粒活性炭净化水有一定的亚慢性毒作用,其表现为动物血清白蛋白下降,血肌酐升高和肝、肾组织出现有意义的病理变化。硒(0.5mg/L)能够减轻上述毒性反应。作用机制可能与硒有效提高动物全血GSH-PX活性和增强细胞免疫功能有关。

In this paper, we studied the subchronic toxicity cellular immunologicfunction and genetic toxicity of drinking water treated by GAC and the protective effects of Selenium (Se) on the toxicity. After treated for 100-days,Kunming and BALB/C mice were sacrificed and samples were collected forinvestigation. The results showed that the treated water had-some harmfuleffects on the animals. which were, manifested as damage of hepatic, and renal function and pathomorphological changes of hepatic and renal tissues. However, no mutagenicity was found. Se(0.5mg/L) in the treated water was ableto mitigate the above toxicological effects on aminals. The mechanism isprobably related to the Se ability to enhance the whole blood glutathione peroxidase activity(GSH-Px). and stimulate the proliferation responseof spleen cells to mitogen LPS.