丁咯地尔配合康复训练对恢复期脑卒中患者运动功能与日常生活活动能力的影响

Effect of buflomedil associated with rehabilitation training on motor function and activities of daily living ability in stroke patients of convalescence period

目的:研究丁咯地尔(buflomedil)对恢复期脑卒中患者运动功能与日常生活活动(ADL)能力的影响及其安全性。方法:82例康复科住院的恢复期脑卒中患者在接受常规康复训练的基础上,数字表法随机分为丁咯地尔治疗组与对照组。治疗组42例,给予丁咯地尔150～200mg静脉滴注;对照组40例,给予血栓通15～20mL静脉滴注。上述药物均1次/d,连续15d为1个疗程。两组患者治疗前、后均采用脑卒中患者临床神经功能缺损(NFD)程度、Fugl-Meyer运动功能(FMA),ADL能力Barthel指数(BI)等量表进行评定。结果:NFD评分:治疗组治疗后为(16.7±6.4)分,明显低于治疗前(24.2±5.5)分(t=5.77,P<0.01)和对照组治疗后(20.1±7.2)分(t=2.27,P<0.05);FMA评分:治疗组治疗后为(66.5±8.1)分,明显高于治疗前(36.8±7.2)分和对照组治疗后(45.7±9.3)分(t=17.78,10.83,P均<0.01);BI评分:治疗组治疗后为(79.4±9.5)分,明显高于治疗前(45.7±8.9)分和对照组治疗后(58.3±8.6)分(t=16.77,10.55,P均<0.01)。丁咯地尔治疗组与对照组的总有效率分别为83%,62%,差异有显著性意义(χ2=4.53,P<0.05)。结论:丁咯地尔治疗恢复期脑卒中患者的疗效肯定,不良反应少。

AIM:To explore the effect and reliability of buflomedil associated with rehabilitation training on motor function and activities of daily living (ADL) ability in stroke patients of convalescence period. METHODS:Eighty two inpatients in the department of rehabilitation medicine with stroke of convalescence period were randomly divided into two groups: buflomedil group and control group. Both groups received regular rehabilitation therapy, besides, the therapy group (n=42) received vein drip of buflomedil 150-200 mg; and the control group (n=40) received vein drip of XueShuantong 15-20 mL, both were once a day and 15 d as a course. The neuro function deficit score (NFD), Fugl Meyer motor assessment (FMA) and modified Barthel index (BI) of ADL of all patients in the two groups were evaluated before and after treatment. RESULTS:The NFD score in buflomedil group after treatment (16.7±6.4) were significantly lower than that of before treatment(24.2±5.5) (t=5.77,P< 0.01) and that in the control group after treatment(20.1±7.2 )(t=2.27,P< 0.05). The FMA score in the buflomedil group after treatment (66.5±8.1) was significantly higher than that of before treatment (36.8±7.2) and that in the control group after treatment (45.7±9.3) (t=17.78,10.83,P< 0.01). The BI scores in the buflomedil group after treatment (79.4±9.5 ) was significantly higher than that of before treatment (45.7±8.9) and that in the control group after treatment (58.3±8.6) (t=16.77,10.55,P< 0.01). The total efficiency rates of the buflomedil group and control group were 83%and 62%, respectively, and the difference was significant (χ2=4.53,P< 0.05). CONCLUSION:There is a positive effect of buflomedil on treatment in stroke patients of convalescence period.