我国β链异常血红蛋白发生率、基因频率和分布

The Incldence、Gene frequency and Distribution of the β chain Abnormal Henoglobin in China

目的研究我国β链异常血红蛋白发生率、基因频率和分布。方法应用群体遗传学研究方法对我国β链异常血红蛋白进行群体遗传学分析。结果我国β链异常血红蛋白平均发生率为0.157％,平均基因频率为7.844×10_(-4),各省区均有β链异常血红蛋白分布,发生率和基因频率各省区不同。结论我国β链异常血红蛋白有高度的分布不均一性和遗传多态性。

Objective To study the incidence、gene frequency and distribution of the β chain abnormal hemoglobin in China. Methods The methods to study the population genetics were used to analyze the β chain abnormal hemoglobin in China. Results The Average incidence of the β chain abnormal hemoglobin in China was 0.157%, average gene frequency was 7.844×10-4.The incidence and gene frequency vary with provinces and auto nomous regions.Conclusions There are distinet distributing heterogeity and genetic polymorphism of the β chain abnormal hemoglobin in China.