天津地区汉族人血小板膜糖蛋白Ib_α基因VNTR多态性的分布

The Distribution of VNTR Polymorphism of the Platelet Membrane Glycoprotein Ib_α in Tianjin Han Nationality

目的 :探讨血小板膜糖蛋白Ibα基因VNTR多态性在天津地区汉族人群中的分布。方法 :聚合酶链反应扩增目的片断 ,根据产物的长度判断VNTR基因型。结果 :天津地区汉族人群等位基因A、B、C、D的频率分别为0.43 % ,3.33 % ,60.14%和36.10 %。结论 :天津地区汉族人群GPIbα基因VNTR多态性分布以等位基因C和D为主。

Objective:To study the distribution of VNTR polymorphism of the platelet membrane glycoproˉtein Ibαin Tianjin Han nationality.Methods:The identification of VNTR polymorphism of the glycoprotein Ibαgene was performed by polymerase chain reaction(PCR).Results:The frequencies of A,B,C and D alleles in Tianjin Han nationality were0.43%,3.33%,60.14%and36.10%respectively.Conclusions:The alleles C and D of VNTR were the main alleles in Tianjin Han nationality.