MAG_3在放射性金属标记应用中的最新研究进展

Recent progress in application of MAG3 labeling radio-metals

综述了利用巯乙酰基三甘氨酸（MAG3）标记的多肽的生物学特性。经 MAG3形成的 Tcm标记物的标 99记率和比放射性高，体内稳定性好，与血清蛋白的非特异性结合低；经 MAG3 形成的186/188Re 标记物也具有良好的体内外稳定性。

The biological behaviors of the labeling conjugates with MAG3 were summarized. The 99Tcm labeling conjugates by using MAG3 show high labeling efficiencies and high specific activities and hold desirable stability in vitro and in vivo. The binding of the labeling conjugates with plasma protein is low; the 186/188Re labeling compounds, using MAG3 as BFCA , also hold desirable stability in vitro and in vivo. So many potentially useful biomolecules labeled by 99Tcm, 186/188Re for diagnosis and therapy may be produced via MAG3.