摘要
线粒体除了作为细胞内的“能量工厂”外,在控制细胞凋亡中起主导作用。细胞凋亡时,线粒体膜通透性增加,释放可溶性线粒体膜间隙蛋白质,进一步破坏细胞结构。在这些致死性蛋白质中,有些(cyt c、Smac/DIABLO、Omi/HtrA2等)能够激活caspases,另一些(endo G、AIF、Omi/HtrA2等)则以非caspase依赖的方式发挥作用。多种线粒体因子参与细胞凋亡,强化了细胞器在凋亡控制中的核心作用。
Mitochondria are 'life-essential' organelles for the production of metabolic energy in the form of ATP. Paradoxically mitochondria also play an important role in the apoptotic-signal-ing pathway. Numerous pro-apoptotic molecules act on mitochondria and provoke the permeabilization of mitochondrial membranes. Soluble proteins contained in the mitochondrial in-termembrane space are released through the outer membrane and participate in the organized destruction of the cells. Among the lethal proteins, some activate caspases (cyt c, Smac/DIABLO, Omi/HtrA2,etc.), whereas others act in a caspase-independent fashion (endo G, AIF, Omi/HtrA2, etc.). The diversity of mitochondrial factors participating in apoptosis emphasizes the central role
of these organelles in apoptosis control.
出处
《细胞生物学杂志》
CSCD
北大核心
2004年第1期29-33,共5页
Chinese Journal of Cell Biology
