活血化瘀、化痰利湿法对大鼠肥胖相关性脂肪肝的作用

Experimental study on the treatment of obesity correlated fatty liver in rats by the therapy promoting blood circulation to remove blood stasis and resolving phlegm and dampness of by diuresis.

目的 探讨活血化瘀、化痰利湿法改善肥胖相关性脂肪肝大鼠胰岛素抵抗状态和对肿瘤坏死因子 α(TNF α)的影响。方法 32只健康雄性SD大鼠随机分成正常组、造模组、西药组、中药组 (活血化瘀、化痰利湿 )。第 16周禁食 2 4小时 ,取血、组织匀浆 ,测定各组大鼠血清和脂肪组织中TNF α。结果 中药组能显著降低大鼠血清和脂肪组织中TNF α水平 (P <0 .0 1)。结论 活血化瘀、化痰利湿法能改善肥胖相关性脂肪肝大鼠胰岛素抵抗状态 ,达到治疗脂肪肝的目的。

Objective To study the improvement of insulin resistance in rats with obesity related fatty liver by the therapy promoting blood circulation to remove blood stasis and resolving phlegm and dampness by diuresis and its effect on tumor necrosis factor α.Methods Thirty-two healthy SD male rats were randomly divided into 4 groups: normol control group, model group, Dong Bao Gan Tai group and herbal therapy group. At 16th week, after fasting for 24 h, the rats were killed. TNF-α concentration in serum and fatty tissue were measured in all groups.Results The herbal therapy could significantly lower the level of TNF-α concentration in serum and fatty tissue of the rats.Conclusion The therapy promoting blood circulation to remove blood stasis, resolving phlegm and dampness by diuresis can improve the insulin resistance in the rats with obesity related fatty liver and effectively treat fatty liver.