摘要
过氧化物酶体增殖物激活受体 (peroxisomeproliferator activatedreceptors ,PPARs)是核受体超家族中的一类配体依赖的核转录因子 ,包括α、β/δ和γ三种亚型 ,在脂肪细胞分化、能量代谢和炎症过程中都发挥重要的作用。最近的研究显示 ,PPARs的活化不仅可以改善包括糖尿病、高血压和肥胖等在内的胰岛素抵抗综合征 ,而且还直接作用于血管壁 ,从而减缓动脉粥样硬化的进程。本综述将就PPARs的结构、功能、与动脉粥样硬化发病机制和治疗相关的最新研究进展进行简要介绍。
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependant nuclear transcription factors, consisting of three isoforms: α,β/δ and γ, which form a subfamily of the nuclear receptors superfamily. PPARs play an important role in adipocyte differentiation, energy metabolism, and inflammation. PPARs' effect goes beyond the improvement of insulin resistance in syndrome X (diabetes mellitus, hypertension, obesity and so on). Through recent years' study, it has been demonstrated that PPARs regulate vascular wall directly, which, therefore, decelerate the development of atherosclerosis. In this review, we will look at current trends of PPARs research in their structure, function, and molecular mechanism related to pathogenesis and therapy of atherosclerosis.
出处
《生理科学进展》
CAS
CSCD
北大核心
2004年第1期13-18,共6页
Progress in Physiological Sciences
基金
国家重点基础发展规划项目 (G2 0 0 0 5 6 90 8)资助课题