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串珠素的生理与病理生理作用 被引量:7

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摘要 串珠素 (perlecan)是细胞外基质中主要的蛋白聚糖之一 ,由核心蛋白和硫酸肝素侧链组成 ,可以通过调节生长因子的结合和活性影响血管壁细胞的增殖、迁移 ,并影响细胞与基质的粘附 ,在机体心血管和软骨发育。
作者 刘秀华
出处 《生理科学进展》 CAS CSCD 北大核心 2004年第1期83-85,共3页 Progress in Physiological Sciences
基金 国家自然科学基金 (30 370 5 6 9) 解放军总医院科研基金(0 1YM30 )资助课题
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参考文献10

  • 1[1]Costell M, Gustafsson E, Aszodi A, et al. Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol,1999,147:1109~1122.
  • 2[2]Costell M,Carmona R,Gustafsson E,et al.Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.Circ Res,2002,91:158~164.
  • 3[3]Arikawa-Hirasawa E, Le AH, Nishino I, et al. Structural and functional mutations of the perlecan gene cause Schwartz-Jampelsyndrome, with myotonic myopathy and chondrodysplasia. Am J Hum Genet,2002,70:1368~1375.
  • 4[4]Belknap JK, Weiser-Evans MC, Grieshaber SS, et al. Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature.Am J Respir Cell Mol Biol,1999,20:24~34.
  • 5[5]Whitelock JM, Graham LD, Melrose J, et al. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells. Matrix Biol, 1999, 18:163~178.
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  • 7[7]Evanko SP, Raines EW, Ross R, et al. Proteoglycan distribution in lesions of atherosclerosis depends on lesionseverity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta. Am J Pathol, 1998, 152:533~546.
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同被引文献63

  • 1庞祖才,许汉权,谢伟坚,胡锐明,李永军,刘建华,杨升平,罗永立,陈永韶.预防椎板切除术后硬膜外粘连的实验研究[J].中国修复重建外科杂志,2006,20(12):1176-1179. 被引量:18
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  • 6Laroccad H,Macnab I.The laminectomy membrane.Studies in its evolution,characteristics,effects and prophylaxis in dogs.J Bone Joint Surg Br,1974,56(3):545-550.
  • 7Jiang X,Couchman JR.Perlecan and tumor angiogenesis.J Histochem Cytochem,2003,51(11):1393-1410.
  • 8Knox S,Merry C,Stringer S,et al.Not all perlecans are created equal:interactions with fibroblast growth factor(FGF)2 and FGF receptors.J Biol Chem,2002,277(17):14657-14665.
  • 9Cross MJ,Claesson-Welsh L.FGF and VEGF function in angiogenesis:signaling pathways,biological responses and therapeutic inhibition.Trends Pharmacol Sci,2001,22(4):201-207.
  • 10da Costa RC,Pippi NL,Graca DL,et al.The effects of free fat graft or cellulose membrane implants on laminectomy membrane formation in dogs.Vet J,2006,171(3):491-499.

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