药物性中性粒细胞减少症患者病因分析及对策

The causes of medicine-induced neutrophilic granulocytopenia and the countermeasures

笔者分析了38例药物性中性粒细胞减少(不包括抗肿瘤药物所致)患者的用药史、家族史及文化背景,发现有14例存在滥用药,6例有家族过敏史,11例对疾病用药情况及相关检查认识不够,其余7例与间断用药有关。采取向患者强调遵医嘱用药的重要性,加强用药宣教,仔细询问病史,教育特殊病人慎用药等措施以降低该病的发生率。

The authors investigated 38 patients with medicine-induced neutrophilic granulocytopenia (NG) in view of their medicine-taking history, family history and culture backgrounds, finding medicine-abusing in 14 cases, family history of hypersusceptibility in 6, lack of recognition of medicine taking and the disease-associated examinations in 7 and irregular medicine taking in 7. The countermeasures they adopted included instructing the patients with the importance of taking medicine in line with doctor's medical orders, enhancing instruction of medicine taking, carefully inquiring about the medical history and instructing the patients to take medicine cautiously to decrease the occurrence rate of NG.