3[3]Van den Ouweland JMW,Lemkers HHPJ.Ruitenbeek W,et al.Mutation in mitoehondrial tRNAlett(UUR)gene in a large pedigrea with mater- nally transmitted type Ⅱ diabetes mellitus and deafness.Nature Gennetics 1992;1:368-371.
4[4]Ballinger SW,Shoffner J M,Headays EV.et al.Maternally rahs mitted diabetes and deafness associated with 10.4kb mitochondtial DNA deletion.Nature with Nature Genetics 1992;1:11-15.
6[7]Van den Ouweland JMW,Lemkes HHPJ,Richatd C,et al.Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associated with a single point mutation m the mitochondrial tRNAlett(UUR)gene.Diabetes 1994;43:746-751.
3[1]ANDERSON S,BANKIERr A T,BARREL B G,et al.Seguence and organization of the human mitochondrial genome[J].Nature,1981,290:457-460.
4[2]LINNANE A W.,MARZUKE S,OZAWA T,et al.Mitochondrial DAN mutation as contributor to agaig and degenerative diseases[J].Lancet,1989,1:642-645.
5[3]TRISLER H,MEDORIR.Mitochondrial DNA alteration as a source of human disorders[J].Neurology,1993,43:280-284.
6[4]GERBITA K O.Does the mitochondrial DNA play a role in the pathogenesis of diseases[J]? Diabetologia,1992,35:1181-1185.
7[5]HOLE U,HARDING A E,MORGAN J A.Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies[J].Meurology,1988,331:717-719.
8[6]WALACE D C,SINGH G,LOTT M T,et al.Mitochondrial DNA mutation assicited with Leber,s hereditary opticneuropathy[J].Science,1998,242:1427-1431.
9[7]GOTO Y,NONAKA I,HORAI S.A mutation in the tRNAleu(uuR) gene associated with MELAS subgroup of mitochondrial encephalomyopathies[J].Nature,1990,348:651-655.
10[8]SHOFFNER J M,LOTT M T,LEZZA A M S,et al.Myocloric epilepsy and ragged-redifiber disease (MERRF) is associated with a mitochondrial DNA tRNA lys mutation[J].Cell,1990,61:93-96.