中老年男性2型糖尿病患者睾酮水平与胰岛素抵抗的关系及补充疗法的疗效

The relationship between the level of androgen in middle-old-aged men with type 2 diabetes mellitus and insulin resistant and the effect of testosterone supplementation

目的 观察中老年男性 2型糖尿病患者睾酮 (testosterone,T)水平与胰岛素抵抗的关系及补充疗法的疗效。方法 测定各组睾酮、空腹血糖及胰岛素水平 ,并填写 PADAM问题测量表。其中一组补充安特尔 (十一酸睾酮 )。结果 中老年 2型糖尿病患者 T水平明显降低 (P<0 .0 5) ,补充安特尔后 ,胰岛素抵抗 (insulin resistance,IR)指数下降 (P<0 .0 5)及男性更年期 (T缺乏 )症状评分明显下降 (P<0 .0 1 )。结论 中老年 2型糖尿病患者的 IR与体内 T水平相关 ,补充治疗后 IR及更年期 (T缺乏 )症状明显改善。

Objective To observe the relationship between the level of testosterone in middle-old-aged men with type 2 diabetes mellitus and insulin resistant (IR); and to investigate the effect of testosterone supplementation. Methods The level of testosterone, fasting serum glucose (FSB) and fasting insulin (FIN) was measured, the PADAM questionnaire was answered, and one group received andriol therapy. Results The level of testosterone in middle-old-aged men with type 2 diabetes was lower than other significantly (P<0.05), and the level of insulin resistance index (IRI) and the score of symptoms of testosterone deficiency decreased obviously after testosterone supplementation (P<0.05). Conclusions The IR in middle-old-aged men with type 2 diabetes was associated with testosterone level, and the IR and all the symptoms of testosterone deficiency were obviously improved after the supplementation therapy.