支气管哮喘患者白细胞介素4和白细胞介素13测定的临床意义

Clinical significant on interleukin-4 and interleukin-13 of serum in bronchial asthma

目的 :探讨血清中白细胞介素 4(IL - 4 )和白细胞介素 1 3(IL - 1 3)在支气管哮喘发病中的作用。方法 :本研究对临床确诊的支气管哮喘 46例 ,与正常对照组 46例 ,分别抽取血清采用ELISA法测定其IL - 4、IL - 1 3的含量。结果 :支气管哮喘急性发作期病人和对照组正常人血清中的IL - 4水平分别为 (460 84± 2 7 1 1 )和 (1 32 97± 2 4 66)ng/L ,二组经t检验后P <0 0 0 1。两组IL - 1 3的水平分别为 (2 3 76± 5 44)和 (1 2 61± 2 49)ng/L ,二组经t检验后P <0 0 0 1。 结论 :哮喘病人IL - 4、IL - 1 3明显高于对照组 ,提示IL - 4、IL - 1 3对哮喘发病有一定的调控作用 ,对支气管哮喘气道非特异性炎症和局部免疫反应起重要作用。

Objective:To evaluate the effect of interleukin-4(IL-4)and interleukin-13(IL-13) of serum on the mechanism of asthma.Methods:The level of IL-4 and IL-13 of serum in 46 patients with acute asthmatic and 46 healthy controls were determined by ELISA.Results:Compared with healthy controls the level of IL-4 and IL-13 with patients was significantly increased(460 ^84±27 ^11)ng/L and (132 ^97±24 ^66)ng/L,P<0.001 and(23 ^75±5 ^44)ng/L and (12 ^61±2 ^49)ng/L,P<0.001.Conclusions:The results showed that IL-4 and IL-13 may be acted on the mechanism of asthma and play an important effect on nonspecific inflammation and local immunoreaction of the airway of bronchial asthma.