男性泌尿生殖道支原体感染及耐药性变迁

Male Urogenital Tract Mycoplasma Infection and Drug-resistance Evolution

目的 :研究男性泌尿生殖道支原体感染及耐药性变迁。 方法 :对 2 0 0 1年及 2 0 0 3年就诊的男性泌尿生殖道感染患者行支原体培养及药敏检测 ,并对药物敏感性的变化进行分析。 结果 :2 0 0 1年 10 9例支原体培养阳性患者中 ,溶脲脲原体 (Uu)占 86 .2 % ,人型支原体 (Mh)占 3.8% ,Uu与Mh混合感染占 10 .1% ;2 0 0 3年 134例支原体培养阳性患者中 ,Uu占 79.1% ,Mh占 4 .4 8% ,Uu与Mh混合感染占 16 .4 %。 2 0 0 3年组与 2 0 0 1组年相比 ,支原体对罗红霉素、氧氟沙星、左旋氧氟沙星、克林霉素、阿奇霉素的耐药率明显增高 ;对交沙霉素、美满霉素及强力霉素的耐药率无明显改变 ;敏感性较高的依次是交沙霉素、强力霉素。 结论 :支原体的耐药率高 ,且随着时间的变化 ,其耐药性也在发生变化。治疗支原体感染时应尽量根据药敏结果用药。

Objective: To investigate the male urogenital tract mycoplasma infection and drug-resistance evolution in 2001 and 2003.Methods: The results of mycoplasma culture and drug sensitivity tests were explored in 2001 and 2003,and the differences of drug sensitivity between the two years were analysed. Results: Of the 109 mycoplasma positive cases in 2001, 86.2% were infected with Ureaplasma urealyticum (Uu), 3.8% with Mycoplasma hominis (Mh), 10.1% with both Uu and Mh; and of the 134 mycoplasma positive cases in 2003, Uu infection accounted for 79.1%, Mh infection 4.48% and Uu and Mh infection 16.4%. Compared with 2001, the drug-resistance rates to roxithromycin, azithromycin, levofloxacin, ofloxacin and clindamycin rose obviously in 2003; but the drug-resistance rates to josamycin, minomycin and doxycycline did not change significantly. As far as the drug sensitivity rate is concerned, josamycin ranked the first, and doxycycline the second. Conclusions: Mycoplasma was a high rate of drug-resistance, and the drug sensitivity evolves with the time. Treatment for mycoplasma should be based on the results of drug sensitivity tests. Josamycin can be used as the first choice.