摘要
报道了由聚甲醛和乙二醇单甲醚与干燥的氯化氢气体反应生成乙二醇甲醚氯甲醚(罗红侧链)的生产工艺。并且对反应时间、温度、醛醚用量、萃取剂等对生产工艺的影响进行了探讨,得到了其最佳合成条件,具有三废排放少,成本低、操作简便、安全等优点。
The preparation of ethylene glycol monomethylether chloromethyl ether(roxithromin lateral chain) by chloromethylation of S-oxane and ethylene glycol monomethylether with dry hydrochloride was reported. The influences of reaction time, temperature, concentration of ether and S-oxane, catalysts and extractive solvents on the process were investigated and the optimum preparation conditions were found. The results showed that this process was environmental friendly, economical and safe to perform.
出处
《化学世界》
CAS
CSCD
北大核心
2004年第2期93-95,共3页
Chemical World
关键词
乙二醇甲醚氯甲醚(罗红侧链)
乙二醇单甲醚
氯化氢
ethylene glycol monomethylether chloromethyl ether(roxithromin lateral chain)
S-oxane
ethylene glycol monomethylether
hydrochloride
