聚焦声束超声终止猴早孕对生殖生理的影响

Influence on Monkey's Generative Physiologyafter Terminating Early Pregnancyby Focused Ultrasound Beams

目的:探讨聚焦声束超声终止猴早孕后对猴生殖生理的影响。方法:5只早孕恒河猴经聚焦声束超声终止早孕后,观察月经的恢复情况和性皮肤的改变,于月经复潮后两个周期用彩色多普勒超声检测子宫的大小、形状以及邻近脏器有无损伤。结果:早孕恒河猴经聚焦声束超声终止早孕后40d左右月经复潮,经量及经期均正常。彩色多普勒超声显示恒河猴子宫大小、形态正常,子宫内膜线清晰可见,邻近脏器未见明显损伤。结论:本文初步显示聚焦声束超声终止猴早孕是安全的,对其生殖生理无影响,具有潜在的临床应用前景。

Objective:To study the influence on monkey's generative physiology after terminating early pregnancy by focused ultrasound beams (FUB). Methods: Five early pregnant macaques were treated with FUB, observing the recovery of menstruation and the change of skin after treatment, which show the hormone level. Two circles after the recovery of menstruation, we estimated the shape and size of uterus and determined if there are some injuries on adjacent organs by color Doppler ultrasonography (CDFI). Results:Men struation of these monkeys came 40 days after treated with FUB to terminate the pregnancy, the volume and lasting period were normal. CDFI shows that the size and shape of uterus were normal , the endometrial line was clear to observe, and there are no injuries on adjacent organs. Conclusion: It is safe to terminate an early pregnancy of monkey model by FUB firstly, and there is no influence on the generative physiology. It has a potential of being applied in clinics.