期刊文献+

缺血性脑血管病与血管生成 被引量:3

Ischemic Cerebrovascular Diseases and Angiogensis
下载PDF
导出
摘要 脑组织缺血后梗死灶周各种血管生成生长因子及其受体表达上调,同时血管内皮细胞增殖和微血管新生,血管新生的程度与患者的预后明显相关。给予血管生成生长因子能起到促进脑血管生长、神经功能恢复和改善预后的作用,从而为脑缺血疾病的治疗提供了新的思路。 The expression of various angiogenesis growth factors and the receptors around the infracted areas increase after cerebral ischemia. At the same time, vascular endothelial cells proliferation, microangiogenesis, and the extent of angiogenesis are significantly correlated with the prognosis of the patients. When angiogenesis growth factors are given, it may have the effects on promoting cerebrovascular growth, neurological function recovery and the improvement of prognosis. Thus, it can provide a new idea in the treatment of cerebral vascular diseases.
出处 《国外医学(脑血管疾病分册)》 2004年第1期67-70,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 缺血性脑血管病 血管生成 血管生成生长因子 脑缺血 基因治疗 ischemic cerebrovascular diseases angiogenesis growth factors angiogenesis
  • 相关文献

参考文献20

  • 1Ernanueli C, Madeddu P. Angiogenesis gene therapy to rescue ischaemic tissues: achievemcnts and future directions. Br J Pharmacol, 2001, 133:951 -958.
  • 2Krupiaski J, Kaluza J, Kumar P, et al. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke, 1994, 25: 1794-1798.
  • 3Marti HJ, Bemaudin M, Bellail A, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral isehemia. Am J Pathol, 2000, 156:965 -976.
  • 4Wei L, Joseph P, Carl M, et al. Collateral Growth and Angiogenesis Around Cortical Stroke. Stroke, 2001, 32:2179 -2184.
  • 5Hayashi T, Abe K, Suzuki H, et al. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke, 1997, 28:2039 -2044.
  • 6Abumiya T, Lucero J, Heo JH, et al. Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia. J Cereb Blood Flow Metab, 1999, 19: 1038 - 1050.
  • 7Gu W, Brannstrom T, Jiang W, et al. Vascular endothelial growth factor-A and -C proteh up-regulation and early angiogenesis in a rat photothrombotic ring stroke model with spontaneous reperfusion. Acta Neuropathol (Berl), 2001, 102:216 -226.
  • 8Slevin M, Krupinski J, Slowik A, et al. Serial measurement of vascular endothelial growth factor and transforming growth factor-betal in senma of patients with acute ischemic stroke. Stroke, 2000, 31:1863 - 1870.
  • 9Krupinski J, Klnnar P, Klnnar S, et al. Increased expression of TGF-beta I in brain tissue after ischemic stroke in humans. Stroke, 1996, 27:852 -857.
  • 10Krupinski J, Issa R, Bujny T, et al. A putative role for platelet-derived growth factor in angiogenesis and ncuroprotection after ischcmic stroke in humans. Stroke, 1997, 28:564-573.

同被引文献11

引证文献3

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部