外源性肺表面活性物质在ARDS中的治疗作用

The role of exogenous surfactant in the treatment of ARDS

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Several studies have demonstrated that alterationsof pulmonary surfactant system contribute to the lung dysfunctionassociated with acute respiratory distress syndrome (ARDS). Therehave been many animal experiments and clinical investigationsevaluating exogenous surfactant in ARDS models or patients. Exog-enous surfactant administration has proven inconsistent as a thera-peutic modality for patients with ARDS. Various factors that mayinfluence a host抯 response to exogenous surfactant, these fac-tors include: the nature and severity of the underlying injury,the surfactant preparation utilized, the amount, frequency, andmethod of surfactant administration, the mode of ventilation usedduring and after surfactant delivery, and the timing or surfactantadministration over the course of the illness.[