脑组织移植物中炎症反应的研究

Study on Inflammatory Reaction in Brain Tissue Grafts

作者将胎龄为15d的Wistar胎鼠大脑皮质全层移植到成年Wistar大鼠大脑皮质3,1,2区内,在21d的脑组织移植物中尚存在着明显的炎症反应:巨噬细胞浸润,小胶质细胞增生,在30d、60d和90d的移植物中神经细胞趋向集中血供较好的区域。移植物中有明显的畸变神经元。宿主脑组织和移植物交界区有成束的有髓神经纤维穿过。本文认为炎症反应与神经细胞发育的关系是:较轻的炎症反应可促进移植物神经元的分化发育,较重的炎症反应可使移值物神经元的迁移受阻、不分层,神经元出现畸变,甚至使整个移植物胶质化。

Whole layer of cerebral cortex of E15 fetal rat was transplanted into cerebral cortex of host rats. In the brain tissue grafts of 21 d there is obvious inflammatory reaction: Macrophages infiltration and microglias proliferation. In the grafts of 30 d,60 d and 90 d,neurons tend to concentrate in the field which has adequate blood supply. There are a number of abnormal neurons in grafts. The bundles of myelinated fiber can be seen in the bounding area between graft and the brain tissue of host. The relationship of the development of neuron and inflammatory reaction are also discussed.