期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗药基因MGMT在人脑星形细胞瘤组织中的表达 被引量：2

下载PDF
导出
摘要 6位甲基鸟嘌呤-DNA甲基转移酶(O6-methylguanine-DNA methyltransferase,MGM T)主要功能是转移并接受DNA双链中鸟嘌呤O6位上异常的烷基,使受损的DNA恢复正常[1].我们检测了MGMT基因在人脑胶质瘤的表达情况,探讨MGMT表达对人脑星形细胞瘤的意义.
作者 赵文元 周晓平 刘建民 姜秀峰 卢旺盛 刘善荣
机构地区 第二军医大学长海医院神经外科 基础医学部组织胚胎学教研室
出处 《药学服务与研究》 CAS CSCD 2001年第1期18-18,24,共2页 Pharmaceutical Care and Research
关键词 星形细胞瘤 抗药性 基因表达调控 肿瘤 甲基转移酶类
分类号 R730.263 [医药卫生—肿瘤]
  • 相关文献

参考文献5

  • 1Koike G, Maki H, Takeya H,et al. Purification, structure, an d biochemical properties of human O6-methylguanine-DNA methyltransferase[J ]. J Biol Chem,1990,265(25):14754.
  • 2Wani G, Wani AA, D'Ambrosio SM. In situ hybridization of human kidn ey tissue reveals cell-type-specific expression of the O6-methylguanine-DNA methyltransferase gene[J]. Carcinogenesis,1992,13(3):463.
  • 3Silber JR, Blank A, Bobola MS,et al. Lack of the DNA repair protei n O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors[J]. Proc Natl Acad Sci USA,1996, 93(14):6941.
  • 4Preuss I, Haas S, Eichhorn U,et al. Activity of the DNA repair pro tein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue[J]. Cancer Detect Prev,1996,20(2):130.
  • 5Kreklau EL, Kurpad C, Williams DA, et al. Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylgu anine in vitro and in vivo[J]. J Pharmacol Exp Ther,1999,291(3):12 69.

同被引文献40

  • 1张晓红,张福荣,籍秀娟,李占荣.KB细胞耐药株的建立及其耐药机制的探讨[J].药学学报,1994,29(4):246-251. 被引量：63
  • 2王明盛,杨正明,陈坚.卡铂、威猛、甲氨蝶呤、尼莫地平联用对脑胶质瘤的抑制作用[J].山东医药,2005,45(10):22-23. 被引量：5
  • 3顾科,张军宁.成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析[J].肿瘤防治研究,2007,34(8):626-628. 被引量：13
  • 4Feun KA, gyre HJ, Townsend JJ, et al. Correlation of tumor 06- methylguanine- DNA methytransferase levels with survival of malignant astrocytoma patients treated with bischoroethylnitrosourea: a Southweast Oneology Group study. J Clin Oncol,1998,16:3 310-3 351.
  • 5Silber JR, Mueller BA, Ewers TG, et al. Comparison of 06-methylguanine-DNA methytransferase activity in brain tumors and adjacent normal brain. Cancer Res, 1993. 53:3416-3120.
  • 6Mineura K, Yanagisawa T, Watanabe K, et al. Human braintumor 06 - methylguanine- DNA methytransferase mRNA and its significance as indicator of selective chloroethy lni trosourea chemotherapy. Int. J. Cancer, 1996,69:420-425.
  • 7Preuss I, Eberhagen I, Hass S, et al. 06-methylguanine- DNA methytransferase activity inbr, east and brain tumors[J]. Int J Cancer. 1995 ,61(3):478.
  • 8Silber JR, Blank A. Bobola sin, et al. I.ack of the DNA repair protein 06-methylguanine-DNA methytransferase in histologically normal brain adjacent to primary human brain tumors[J].Proc Natl Acad Sci USA, 1996,93(14) :545.
  • 9Mineura K, Izumi I, Watanabe K, et al. Enhancing effect of 06-alkylganine derivativeson chloroethylyni-trosourea cytotoxicity toward tumor cells[J]. J Cancer, 1994,58(8) :856.
  • 10Hongeng S, Brent TP, Sanford RA, et al. Rapid. 06 - methylguanine-DNA methytransferase protein levels in pediatric brain tumors[J]. Cancer Res, 1997,3 (12Pt1) : 278.

引证文献2

二级引证文献6

药学服务与研究
2001年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部