墨旱莲乙酸乙酯总提物对免疫抑制小鼠免疫功能的影响

Effect of Ethyl acetate extract of Herba Eclipta on immune function in immunosuppressive mice

目的 :研究墨旱莲乙酸乙酯总提物 (EAEEP)对机体免疫功能的调节作用。方法 :采用腹腔注射氢化可的松或环磷酰胺所致免疫抑制小鼠模型 ,观察EAEEP对非特异免疫、体液免疫及细胞免疫功能的影响。结果 :EAEEP能显著提高免疫抑制小鼠的免疫脏器指数、溶血素水平及外周血T淋巴细胞CD4亚群比例 ,并显著增强机体迟发性超敏反应。结论

Objective:The regulatory effects of ethyl acetate extract of Herba Eclipta EAEE on immune function were studied.Methods: The experimental immunosuppressive models were induced by injection of Cyclophosphamide or hydrocortisonc.Results: The index of thymus gland spleen in immunosuppressive mice was increased significantly. when large and small dose of EAEEP were given. EAEE remarkably enhanced the delayed type hypersensitivity in immunosuppressive mice. Conclusions: EAEE possesses notable immunomodulatory action on immune system in mice.