复灌性局部脑缺血大鼠的学习记忆行为障碍

DISTURBANCE OF LEARNING AND MEMORY IN RATS WITH LOCAL CEREBRAL ISCHEMIA REPERFUSION

用避暗法和穿梭箱法研究了局部脑缺血-再灌注雄性Wistar大鼠学习行为。脑缺血一再灌注损伤后3天,被动回避反应已有障碍,缺血-灌注组的测验日潜伏期较假手术组显著缩短(P<0.05)。术后7天,缺血-再灌注组的回避反应少于假手术组,在训练的第一天尤其如此(P<0.01)。这些结果表明局部脑缺血-再灌注大鼠的两种学习行为均有损害,并提示这种大鼠可用作血管性痴呆的动物模型。

Learning behavior in adult male wistar rats exposed to focal cerebral ischemia—reperfusion were investigated in one—t(?)al passive avoidance (step—through) and two—way active avoidance tasks (shuttle—box). Three days after cerebral ischemia—reperfusion, learning in one—trial passive avoidance tasks was disturbed. The incubtion period on the test day in ischemic—reperfused rats was shorter than that in sham-operated rats (p<0.05). Seven days after operation, the focal cerebral ischemia—reperfused rats were also impaired acquisition of two—way active avoidance response. The number of avoidance responses in ischemic—reperfused rats were fewer than that in sham-operated ones, especially like that on the first day in training (p<0.01) These results suggest that rats with focal cerebral ischemia—reperfusion are impaired in two different types of learning tasks, and may be usefull as an animal model for the vascular type of dementia.