瘦素及瘦素受体在子宫内膜癌组织中的表达

The Expression of Leptin and Leptin Receptor in Human Endometrial Carcinoma

目的 :探讨瘦素及瘦素受体在子宫内膜癌发生、发展中的临床意义。方法 :应用免疫组化方法检测了 6 0例正常月经周期的子宫内膜 ,其中增殖期 2 4例 ,分泌期 36例 ;7例子宫内膜单纯增生 ;5例非典型增生和 2 3例子宫内膜癌 ,了解其内膜组织中瘦素及瘦素受体的表达情况。结果 :在各期子宫内膜中均显示瘦素及瘦素受体的表达。①正常月经周期中瘦素受体在分泌期子宫内膜组织中明显高于增殖期子宫内膜 ,差异有非常显著性 (P <0 0 1) ,但瘦素在两者间差异无显著性 (P >0 0 5 ) ;②瘦素及瘦素受体在子宫内膜单纯增生、非典型增生及子宫内膜癌的子宫内膜组织中分别与正常月经周期的分泌期相比较 ,前者表达均低于后者 (P <0 0 5或P <0 0 1) ;③瘦素在子宫内膜癌组织和非典型增生的子宫内膜组织中分别与正常子宫内膜增殖期比较 ,前者均显示较低水平表达 (P <0 0 1) ;④瘦素及瘦素受体在子宫内膜癌、非典型增生以及子宫内膜单纯增生组织中的表达各不相同 ,但两两比较差异无显著性 (P >0 0 5 )。结论 :瘦素及瘦素受体的异常表达与子宫内膜癌的发生有一定关系 ,且瘦素的表达在单纯增生—非典型增生—子宫内膜癌的发展过程中呈现递减趋势。

Objective:To study the clinical significance of leptin and leptin receptor in pathogenesis of endometrial carcinoma.Methods:The immunohistochemical SP method was used to determine the leptin and leptin receptor expression in 60 cases of normal menstrual cycle (including 24 proliferative stage and 36 secretory stage),7 of simple hyperplasia of endometrium,5 of atypical hyperplasia of endometrium,and 23 of endometrial carcinoma.Results:The results revealed that the leptin and leptin receptor expression existed in each kind of samples.①In normal cycle endometrium,the expression of leptin receptor in secretory endometrium was significantly higher than that of in proliferative stage( P <0.01).There was no difference in leptin expression between two stages( P <0.05).②Comparing with secretory endometrium in normal cycle,the expression of leptin and leptin receptor were lower in simple hyperplasia,atypical hyperplasia of endometrium,and endometrial carcinoma( P <0.05 or P <0.01).③Comparing with proliferative endometrium of normal cycles,leptin level was lower in atypical hyperplasia and endometrial carcinoma( P <0.01).④There were no significant differences in the expression of leptin and leptin receptor among endometrial carcinoma,atypical hyperplasia and simple hyperplasia of endometrium( P <0.05).Conclusions:There is certain relationship between the expression of leptin and leptin receptor in endometrium and the pathogenesis of endometrial carcinoma.And the expression of leptin appeared a decreased trend from simple hyperplasia to atypical hyperplasia,and to endometrial carcinoma.