庆大霉素治疗小儿感染性疾患66例的血药浓度测定

Survey of serum gentamicin concentration in treating infections in 66 children

本文对66例感染性疾患患儿(男36,女30;年龄4±3a)肌注(分2组)和静滴庆大霉素进行药物动力学和药效学研究。结果:K分别为0.51±0.12,0.50±0.17和0.92±0.26h^(-1);T_(1/2)分别为1.5±0.4,1.5±0.5和0.8±0.3h;V_d分别为0.32±0.08,0.36±0.11和0.19±0.06L/kg。为使C_p达到4-8mg/L,肌注或快速静滴的单次剂量应选年龄<5a者为2.0-2.5mg/kg;≥5a者为2.0mg/kg(均bid给药)。快速静滴法疗效优于静脉qd给药。

Pharmacokinetics and pharmacodynarnics were studied on 66 children (M 36, F 30; age 4+3a) following intramuscular injection (2 groups) and intravenous infusion of gentamicin. The pharma.cokinetic parameters were K=0.51+0.12, 0.50 + 0.17 and 0.92+0.26h-1 T1/2 = 1.5 + 0.4, 1.5 + 0.5 and 0.8 + 0.3h; Vd=0.32+0.08, 0.36 + 0.11 and 0.19 +0.06L/kg, respectively. The dose of gentamicin which attained a peak concentration 4-8mg/L was 2.0-2.5mg/kg for age<5a, 2.0mg/kg for>5a, bid, by im or rapid iv infusion. Rapid iv infusion bid was more effective than infusion qd.