24小时动态血压监测评价硝苯啶缓释片长效降压效应

Twenty-four-hour ambulatory blood pressure monitor in the evaluation of slow release nifedipine

20例高血压患者中10例用台式自动测压仪测12h血压,比较普通片及缓释片硝苯啶的快速降压作用;另10例用携带式24h动态血压监测仪观察服硝苯啶缓释片前及后d1,d7时24h血压。结果证实硝苯啶缓释片降压疗效明显优于普通片,可达24h,作用缓和,副作用少,并发现24h动态血压监测是研究长效降压药降压效应的好工具,值得进一步使用。

To investigate the effects of slow-release formulation nifedipine (SRN) in essential hypertensive patients, a 2-part study was conducted. Part A consisted of measuring blood pressure with non-invasive automated blood pressure monitor (n= 10). Part B consisted of studying 24 h ambulatory blood pressure monitor (24 h ABPM) in the other 10 patients. In part A, the antihypertensive efficacies of slow-release formulation and conventional nifedipine were compared in each patient 12 h after administration. In part B, 24 h ABPM was used to evaluate the duration effect of SRN by comparing the effects after first day of SRN and after 7 d of using SRN. We found that 24 h ABPM has significant advantages over non-invasive automated blood pressure monitory. One example is that nocturnal blood pressure which measured with 24 h ABPM is more accurate. Therefore, this study suggests that the new formulation, SRN has long term and moderate antihypertensive efficacy during the day and the night and less side effects than the conventional formulation.