3种剂量尼群地平治疗轻型原发性高血压病61例

Three different dosages of nitrendipine for mild essential hypertension in 61 patients

81例轻型高血压病,其中尼群地平(尼)组61例(男51例,女10例,年龄46±10a),分成尼1,2,3组,剂量10,20,30mg/d。阿替洛尔(阿)组20例(男14例,女6例,年龄44±11a),剂量50mg/d。各组均用至4wk后减半量治疗至3mo。治疗4wk后降压幅度各组均有显著下降(P<0.01),其中尼2组优于阿组,P<0.05。经减量至3mo后,尼2,3组血压仍稳定在wk4的有效水平。

In a randomized controlled trial, nitrendipine or atenolol was given t 81 patients with essential hypertension. Sixty one patients (M 51, F 10; age 46+ s 10 a) were treated with 3 different dosages of nitrendipine (10, 20, and 30 mg/d). And 20 patients (M 14, F6; age 44 + 11 a) received atenolol 50 mg/d as controls. The drugs were given bid po for 4 wk, then given a half dose qd for 2 mo(up to ,imo). The results showed that the overall response rate of 20 mg/d group was 85% ,the control (atenolol) group was 60 %, (P<0.05). All blood pressures decreased significantly within 4 wk. After 3 mo treatment, in nitrendipine 10 and 15 mg/d groups the response rates remained to be 87 %; nitrendipine groups showed no change in cholesterol (TC), triglyceride (TG) and beta-lipoprotein (B-LP), but HDL-ch in-creased (P<0.01); and atenolol group showed that HDL-ch decreased (P<0.01) TG and B-LP slightly increased (P>0.05). It is concluded that nitrendipine groups showed better clinical effects than that of the atenolol group.